1887 (Meiji 20)	Umekichi Ito opens a wholesale business of Chinese herbs in Doshomachi, Osaka (currently Chuo-ku, Osaka)
1941	Closed due to war
March 1966 (Showa 41)	Yukichi Ito revitalizes the Chinese herbal medicine wholesale business in Kamikosaka, Higashi-Osaka Started manufacturing and selling healthy tea while wholesale of crude drug raw materials
March 1973 (Showa 48)	Moved to Wakae Higashimachi, Higashi Osaka City due to business expansion
March 1976 (Showa 51)	Reorganized to Ito Hanpo Pharmaceutical Co., Ltd. (capital: 800 million yen) and started manufacturing pharmaceutical products at the same time.
March 1986 (Showa 61)	Established Business Headquarters (Headquarters, Nishiiwata, Higashi Osaka City)
March 1986 (Showa 61)	Increased the capital to 2400 million yen.
April 1990 (Heisei 2)	Opened Mizuhai Factory (Mizuhai, Higashi Osaka City) Started integrated production of Chinese herbal extracts and food extracts
April 1990 (Heisei 2)	Opened Ikeshima Factory (Shinikeshima, Higashi Osaka City) Started integrated production of crude drugs
April 1990 (Heisei 2)	Opened a distribution center (Kano, Higashi-Osaka City)
April 1991 (Heisei 3)	Opened the Kano Factory (in the Kano Industrial Park in Higashi Osaka City). Started integrated production of various bath salts
April 1994 (Heisei 6)	Relocated the distribution center (Kano, Higashi Osaka City)
April 1994 (Heisei 6)	Started manufacturing soft capsules at Mizuhai Factory
April 2000 (Heisei 12)	Established Hangzhou Ito Chinese Health Foods Co., Ltd. in Hangzhou City, Zhejiang Province, China Started manufacturing soft capsules
April 2000 (Heisei 12)	Opened Higashi Osaka Factory (Aramotonishi, Higashi Osaka City) Partially relocated the equipment of the Mizuhai factory and started manufacturing soft capsules, cosmetics, and soft drinks.
April 2000 (Heisei 12)	Expanded the Kano Factory (Kano, Higashiosaka City). The Mizuhashiri, Wakae and Ikeshima factories were relocated and consolidated, and operations began as a comprehensive factory for the integrated production of herbal medicines, herbal extract preparations, health foods, tea, quasi-drugs and cosmetics.
April 2001 (Heisei 13)	Started manufacturing hard capsules at Higashi Osaka Factory
April 2003 (Heisei 15)	Hangzhou Ito Chinese Health Food Co., Ltd. was relocated and started operation as a general factory that produces health foods, quasi-drugs and cosmetics.
April 2005 (Heisei 17)	Headquarters moved to Nagatahigashi XNUMX-chome, Higashi-Osaka
April 2005 (Heisei 17)	Obtained quality management system (ISO9001) certification at Kano Factory and Higashi Osaka Factory
April 2005 (Heisei 17)	Increased capital to 20 yen
April 2008 (Heisei 20)	Obtained GMP (Good Manufacturing Practice) certification for health foods at the Higashi Osaka Factory
April 2010 (Heisei 22)	Obtained GMP (Japan Health and Nutrition Food Association) certification for health supplements at Kano Factory
April 2011 (Heisei 23)	Started manufacturing denture cleaner at Kano Factory.
April 2013 (Heisei 25)	Started manufacturing pills and sugar coating at Kano factory
April 2014 (Heisei 26)	"Vineffle Pomegranate Black Vinegar Drink" and "Vineffle Blueberry Black Vinegar Drink" won the Monde Selection Award Gold award
April 2014 (Heisei 26)	Reduced capital to 9900 million yen
April 2015 (Heisei 27)	"Oysters with Shijimi, Turmeric + Ornithine" and "Metapro Green Juice" won gold medals at the Monde Selection
April 2022 (Reiwa 4)	Comprehensive cooperation agreement concluded with Higashiosaka City